- TRPS1 expression in non-melanocytic cutaneous neoplasms: an immunohistochemical analysis of 200 cases
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Yi A. Liu, Phyu P. Aung, Yunyi Wang, Jing Ning, Priyadharsini Nagarajan, Jonathan L. Curry, Carlos A. Torres-Cabala, Doina Ivan, Victor G. Prieto, Qingqing Ding, Woo Cheal Cho
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J Pathol Transl Med. 2024;58(2):72-80. Published online February 26, 2024
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DOI: https://doi.org/10.4132/jptm.2024.01.23
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Abstract
PDFSupplementary Material
- Background
Although trichorhinophalangeal syndrome type 1 (TRPS1) was initially thought to be highly sensitive and specific for carcinomas and mesenchymal tumors of mammary origin, more recent data suggest its expression is not limited to breast neoplasms but also can be seen in other cutaneous neoplasms, such as extramammary Paget disease and squamous cell carcinoma (SCC) in situ.
Methods Two-hundred cases of non-melanocytic cutaneous neoplasm, including basal cell carcinomas (BCCs) (n = 41), SCCs (n = 35), Merkel cell carcinomas (MCCs) (n = 25), and adnexal neoplasms (n = 99), were tested for TRPS1 expression using a monoclonal anti- TRPS1 rabbit anti-human antibody.
Results TRPS1 expression was present in almost all cases of SCC (94%), with a median H-score of 200, while it was either absent or only focally present in most BCCs (90%), with a median H-score of 5. The difference between BCCs and SCCs in H-score was significant (p < .001). All MCCs (100%) lacked TRPS1 expression. TRPS1 expression was frequently seen in most adnexal neoplasms, benign and malignant, in variable intensity and proportion but was consistently absent in apocrine carcinomas. All endocrine mucin-producing sweat gland carcinomas (EMPSGCs) (100%, 6/6) showed diffuse and strong TRPS1 immunoreactivity, with a median H-score of 300, which was significantly different (p < .001) than that of BCCs.
Conclusions Our study shows that TRPS1 may be an effective discriminatory marker for BCCs and SCCs. It also has a role in distinguishing BCCs from EMPSGCs.
- Crystal-Storing Histiocytosis with Plasma Cell Neoplasm in the Setting of Chronic Carbamazepine Exposure
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Woo Cheal Cho, Safina Hafeez, Peter Shen
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J Pathol Transl Med. 2019;53(2):142-144. Published online June 7, 2018
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DOI: https://doi.org/10.4132/jptm.2018.05.25
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Mousa Mobarki, Alexandra Papoudou-Bai, Jean Marc Dumollard, Abdulaziz H. Alhazmi, Shaqraa Musawi, Mohammed Ali Madkhali, Khalid Y. Muqri, Michel Péoc’h, Georgia Karpathiou Diagnostics.2023; 13(2): 271. CrossRef - Immunoglobulin-Storing Histiocytosis: A Case Based Systemic Review
Hanne Wiese-Hansen, Friedemann Leh, Anette Lodvir Hemsing, Håkon Reikvam Journal of Clinical Medicine.2021; 10(9): 1834. CrossRef - Carbamazepine
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- Rare Manifestations of Churg-Strauss Syndrome with Mediastinal and Hilar Lymphadenopathies: Report of an Autopsy Case
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Woo Cheal Cho, Bharat Ramlal, Mary Fiel-Gan, Xianyuan Song
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J Pathol Transl Med. 2019;53(1):66-69. Published online December 18, 2017
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DOI: https://doi.org/10.4132/jptm.2017.12.13
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Hisashi Sasaki, Jun Miyata, Ryohei Suematsu, Yoshifumi Kimizuka, Yuji Fujikura, Yoshiko Kichikawa, Hiroaki Sugiura, Kenji Itoh, Akihiko Kawana Allergology International.2022; 71(4): 536. CrossRef
- Expression of CD34 and β-Catenin in Malignant Rhabdoid Tumor of the Liver Mimicking Proximal-Type Epithelioid Sarcoma
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Woo Cheal Cho, Fabiola Balarezo
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J Pathol Transl Med. 2018;52(3):195-197. Published online July 7, 2017
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DOI: https://doi.org/10.4132/jptm.2017.05.15
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